Renal Replacement Therapy in Severe Burns: A Multicenter Observational Study.

"After multilevel institutional review board approval, a multicenter observational study was conducted; concurrent with the American Burn Association’s Randomized controlled Evaluation of high-volume hemofiltration in adult burn patients with Septic shoCk and acUte kidnEy injury (RESCUE) trial, Clinicaltrials.gov Registration Number: NCT01213914. All adult patients aged 18 or older, admitted with severe burns placed on RRT for acute indications during their hospitalization but not randomized into the RESCUE trial, were included. Patients already on dialysis for end-stage renal disease (ESRD) at the time of admission were excluded. As the RESCUE trial was already enrolling subjects when this protocol was written, patients placed on RRT before approval of this protocol were identified retrospectively. On approval of the study at each study site, patients were prospectively enrolled after obtaining informed consent from either the patient or the legal authorized representative when patients were not able to give their own consent."