Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936.

"Disclosure statement The authors have no actual or potential conflicts of interest."

"The authors thank the Lothian Birth Cohort 1936 members who took part in this study, radiographers at the Brain Research Imaging Centre, and Lothian Birth Cohort 1936 research associates who collected and entered some of the cognitive data used in this article. This research and LBC1936 phenotype collection were supported by Research into Ageing and continues as part of the Disconnected Mind project, funded by Age UK; by the UK Medical Research Council [G0701120, G1001245, MR/M013111/1]. This work was undertaken within The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology (www.ccace.ed.ac.uk), part of the cross council Lifelong Health and Wellbeing Initiative [MR/K026992/1], for which funding from the BBSRC and MRC is gratefully acknowledged. This work was partially supported by the Row Fogo Charitable Trust [BRO-D.FID3668413; The Row Fogo Centre for Research into Ageing and the Brain]. Magnetic Resonance Image acquisition and analyses were conducted at the Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh (www.bric.ed.ac.uk) which is part of SINAPSE (Scottish Imaging Network–A Platform for Scientific Excellence) collaboration (www.sinapse.ac.uk) funded by the Scottish Funding Council and the Chief Scientist Office. Funding from the European Union Horizon 2020, PHC-03–15, [project No 666881], “SVDs@Target”, the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease, [ref no. 16 CVD 05] and the UK Dementia Research Institute at The University of Edinburgh is gratefully acknowledged."