ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function.

"Disclosure statement The authors have no actual or potential conflicts of interest."

"Funding: This work was supported by Heaton-Ellis Trust, Motor Neurone Disease Association, Medical Research Council, the Wellcome Trust, the Noreen Murray Foundation, the American ALS Association, and Project MinE. This is an EU Joint Program–Neurodegenerative Disease Research (JPND) project. The project is supported through the following funding organizations under the aegis of JPND–www.jpnd.eu (United Kingdom, Medical Research Council and Economic and Social Research Council) and Horizon 2020 Program (H2020-PHC-2014-two-stage; grant agreement number 633413). BNS is supported by a Medical Research Fund fellowship. CES and AA-C receive salary support from the National Institute for Health Research (NIHR) Dementia Biomedical Research Unit at South London and Maudsley NHS Foundation Trust and King's College London. Samples used in this research were in part obtained from the UK National DNA Bank for MND Research, funded by the MND Association and the Wellcome Trust. Funding was provided to JEL by the National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS) (R01NS073873) and the American ALS Association."