Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection.

"This work was supported by the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR). In UK, this work was also supported by the Medical Research Council [grant number MR/N501852/1] and by the Biotechnology and Biological Sciences Research Council [grant number BB/R012415/1]. The authors thank Richard Svensson and Uppsala University Drug Optimisation and Pharmaceutical Profiling Platform (UDOPP) for their assistance in the measurements of metabolic stability, and XenoGesis (Nottingham, UK) for their assistance in the in vivo studies. We are grateful to Simulations Plus (Lancaster, CA) for providing the Drug Delivery Group at the Department of Pharmacy, Uppsala University with a reference site license for the software ADMET PredictorTM."