The inhibition of thymidine phosphorylase can reverse acquired 5FU-resistance in gastric cancer cells.

"Conflict of interest Kazuhiro Y. has received grants and personal fees and honoraria from Taiho Pharmaceutical Co., Ltd., and had a consultant or advisory relationship with Taiho Pharmaceutical Co., Ltd. Outside of the submitted work, Kazuhiro Y. has received grants and personal fees from Pfizer Inc., Chugai Pharmaceutical Co., Ltd., and Yakult Honsha Co., Ltd.; grants from Bristol-Myers Squibb and Kyowa Hakko Kirin Co., Ltd.; honoraria from Pfizer Inc., Chugai Pharmaceutical Co., Ltd., Kyowa Hakko Kirin Co., Ltd., and Yakult Honsha Co., Ltd., and had a consultant or advisory relationship with La Roche, Ltd. All of the remaining authors declare that they have no conflicts of interest."

"This work was supported by Grants-in-Aid for Scientific Research (C) (Grant no. 16K10496) from the Ministry of Education, Culture, Sports, Science and Technology and Taiho Pharmaceutical Co., Ltd. Human rights statementAll procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.: Animal studiesThis article does not contain any studies with human or animal subjects performed by any of the authors.: Conflict of interestKazuhiro Y. has received grants and personal fees and honoraria from Taiho Pharmaceutical Co., Ltd., and had a consultant or advisory relationship with Taiho Pharmaceutical Co., Ltd. Outside of the submitted work, Kazuhiro Y. has received grants and personal fees from Pfizer Inc., Chugai Pharmaceutical Co., Ltd., and Yakult Honsha Co., Ltd.; grants from Bristol-Myers Squibb and Kyowa Hakko Kirin Co., Ltd.; honoraria from Pfizer Inc., Chugai Pharmaceutical Co., Ltd., Kyowa Hakko Kirin Co., Ltd., and Yakult Honsha Co., Ltd., and had a consultant or advisory relationship with La Roche, Ltd. All of the remaining authors declare that they have no conflicts of interest."