Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease.

"Disclosures Authors declare no conflicts of interest."

"We wish to thank our human brain tissue donors and their families for their valuable contributions to this work. We also thank Marshall Dozier and Malcom McLeod from CAMARADES for their advice on the systematic search. This work was funded by the UK Dementia Research Institute, the European Research Council (ALZSYN), Alzheimer's Research UK and the Scottish Government Chief Scientist Office, the Wellcome Trust, and Alzheimer's Society. TSJ gratefully acknowledges affiliations with the FENS‐Kavli Network of Excellence, the Centre for Dementia Prevention, the Euan MacDonald Centre, and Edinburgh Neuroscience. The two control participants were from the Lothian Birth Cohort 1936, thus, we wish to thank the cohort and research team supported by Age UK (Disconnected Mind project) in The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) ((MR/K026992/1)."