In vivo visualization of age-related differences in the locus coeruleus.

"mt-weighted images were then bias-corrected (n4-itk) ( ) and spatially normalized to a studywise space using a highly iterative coregistration routine available from the ants v2 1 software package ( http://stnava github io/ants )."

"Disclosure The authors have no actual or potential conflicts of interest."

"The authors thank the reviewers for their helpful comments. The views expressed are those of the authors and not necessarily those of the NHS or the Department of Health. RH is supported by the UCLH NIHR BRC. DH is supported by the Medical Research Council (Grant Ref: MR/P012698/1), German Academic Exchange Service (ID 91515956), Human Brain Project (SP3 WP 3.3.1) and SFB (Sonderforschungsbereich) 779, Project A7. The Wellcome Centre for Human Neuroimaging is supported by core funding from the Wellcome (203147/Z/16/Z). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1). Additional support to RNH and RAK was from the Medical Research Council (grants SUAG/010 RG91365 and SUAG/014 RG91365) and the European Union's Horizon 2020 research and innovation program under grant agreement No 732592. The authors are grateful to the Cam-CAN respondents and their primary care teams in Cambridge for their participation in the Cam-CAN study. They also thank colleagues at the MRC Cognition and Brain Sciences Unit MEG and MRI facilities for their assistance. The Cam-CAN corporate authors are listed here: http://www.cam-can.com/index.php?content=corpauth#12."