rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial.

"Funded by Shire. Shire participated in the design of the study, the collection and analysis of data, and preparation of the clinical study report. D.L. and I.H-P. hold stock/stock options in Premalux AB, and received consulting fees from Shire. B.H. received consulting fees from Premacure AB and Shire. L.R. received consulting fees and research support from Shire. N.M. received consulting fees from Shire, and partial funding from the Department of Health’s National Institute for Health Research Biomedical Research Centre’s funding scheme at University College London Hospitals/University College London. K.B., F.B., J.H., O.M-N., M.vW., and L.S. received consulting fees from Shire. D.D. received consulting fees from Shire, and received consulting fees from Ipsen regarding other indications for IGF-1 therapies. N.B., A.T., M.H., E.J., A.M., and J-K.C. are employees of and own stock/stock options in Shire. M.T.’s university received consulting fees from Shire. A.H. holds stock/stock options in Premalux AB, and received consulting fees from Shire. C.D., A.M., P.R, and C.G. declare no conflicts of interest."

"Funded by Shire. Shire participated in the design of the study, the collection and analysis of data, and preparation of the clinical study report. D.L. and I.H-P. hold stock/stock options in Premalux AB, and received consulting fees from Shire. B.H. received consulting fees from Premacure AB and Shire. L.R. received consulting fees and research support from Shire. N.M. received consulting fees from Shire, and partial funding from the Department of Health’s National Institute for Health Research Biomedical Research Centre’s funding scheme at University College London Hospitals/University College London. K.B., F.B., J.H., O.M-N., M.vW., and L.S. received consulting fees from Shire. D.D. received consulting fees from Shire, and received consulting fees from Ipsen regarding other indications for IGF-1 therapies. N.B., A.T., M.H., E.J., A.M., and J-K.C. are employees of and own stock/stock options in Shire. M.T.’s university received consulting fees from Shire. A.H. holds stock/stock options in Premalux AB, and received consulting fees from Shire. C.D., A.M., P.R, and C.G. declare no conflicts of interest. We thank Rui Tang, an employee of Shire, who provided assistance with additional statistical analysis. We also thank Valérie Boissel, PhD, and Rosalind Bonomally, MSc, of Excel Scientific Solutions, who provided medical writing assistance funded by Shire. The authors thank the infants, their families, and the investigators/contributors who participated in this study (list of participants available at www.jpeds.com [Appendix 1])."

"Trial registration ClinicalTrials.gov: NCT01096784."