Development of a technology-based behavioral vaccine to prevent adolescent depression: A health system integration model.

"☆☆: Disclosures: Benjamin W. Van Voorhees has served as a consultant to Prevail Health Solutions, Inc., Mevident Inc., San Francisco and Social Kinetics, Palo Alto, CA, and the Hong Kong University to develop Internet-based interventions. In order to facilitate dissemination, the University of Chicago agreed to grant a no-cost license to Mevident Incorporated (3/5/2010) to develop a school-based version. Neither Dr. Van Voorhees nor the university will receive any royalties or equity. Dr. Van Voorhees agreed to assist the company in adapting the intervention at the rate of $1000/day for 5.5 days."

"Thanks to Myrna Grant for her support with clinic coordination at UIC, to Mary Harris for her management of the Boston, MA study site, and to Ruth Ross for her contribution to the initial intervention design. Research reported in this article was supported by the National Institute of Mental Health of the National Institutes of Health under award numbers K08MH072918 and R01MH090035. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Ethical bodies that approved this study include: Wellesley College Institutional Review Board (IRB), University of Illinois IRB, Advocate Health Care IRB, Franciscan St. Mary IRB, Northwestern IRB and Northshore University Healthsystem IRB. Funding source: Supported by a career development award from the National Institutes of Mental Health grants K-08 MH 072918-01A, Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT) and 1 RO1 MH090035-01A1Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT), Clinical Trial Registry (clinicaltrials.gov): NCT01893749. The future of Internet-based behavior change interventions may largely be shaped by the degree to which they actually prevent chronic disease through improving outcome and reducing costs, rather than by how well they manage the disease. To achieve these dual goals, a family of interventions needs to be developed around these focused requirements for prevention within health systems. However, without careful attention to implementation factors, the interventions may not achieve their potential. Funding agencies, investigators and health care organizations will need to consider the importance of investing resources and expanding administrative capacities to manage and develop technology based behavioral vaccines."