A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency.

"CONFLICTS OF INTEREST Guarantor of the article: Martti Färkkilä, MD, PhD. Specific author contributions: M.F. and M.S. designed the study, coordinated the project, and participated in writing the article; T.M. and S.P. collected the data and participated in statistical analyses and writing; A.R. reanalyzed and scored histology of atrophic gastritis and duodenal inflammation; S.S. performed laboratory analyses and participated in writing the article; T.M., M.S., S.P., and M.F. provided clinical care for the patients. All authors have read and approved the final manuscript. Financial support: M.S. and T.M. have received honoraria from the CSL Behring, but this work was independent of the honoraria. The remaining authors declare no competing financial interests. This work was supported by the Finnish Medical Foundation, the Helsinki University Hospital Research Funds, the Sigrid Jusélius Foundation, and the Mary and Georg C. Ehrnrooth Foundation. Potential competing interests: None. Study HighlightsWHAT IS KNOWN✓ CVID associates with a wide spectrum of autoimmune diseases.✓ The frequency of GI infections and inflammatory diseases is poorly documented in patients with CVID.WHAT IS NEW HERE✓ CVID associates with a high prevalence of GI infections, chronic inflammation of the GI tract, and malignancies.✓ GI inflammation increases fecal calprotectin and occurs more frequently in patients with CVID with clearly low B-cell counts."

"Financial support: M.S. and T.M. have received honoraria from the CSL Behring, but this work was independent of the honoraria. The remaining authors declare no competing financial interests. This work was supported by the Finnish Medical Foundation, the Helsinki University Hospital Research Funds, the Sigrid Jusélius Foundation, and the Mary and Georg C. Ehrnrooth Foundation."