Activation-Induced Cytidine Deaminase Regulates Fibroblast Growth Factor/Extracellular Signal-Regulated Kinases Signaling to Achieve the Naïve Pluripotent State During Reprogramming.

"thus our study identifies aicda as a novel regulator of naive pluripotency through its activity on fgf/erk signaling stem cells2019;37:1003-1017 ipscs dna methylation epigenetics mitogen-activated protein kinase signaling source-schema-version-number 2 0 component-id stem3023 cover-date august 2019 details-of-publishers-convertor converter:wiley_ml3gv2_to_nlmpmc version:5 6 9 mode:remove_fc converted:30 09 2019 data availability statement: raw rna-seq data are available in a public depository accession number: gse129223.; raw errbs data are available in a public depository accession number: gse129223.; raw rna-seq data are available in the geo public depository accession number: gse129223.; raw errbs data are available in the geo public depository accession number: gse129223.; data availability statement raw rna-seq data are available in a public depository accession number: gse129223.; raw errbs data are available in a public depository accession number: gse129223. data availability statement: raw rna-seq data are available in a public depository accession number: gse129223"

"Disclosure of Potential Conflicts of Interest The authors indicated no potential conflicts of interest."

"We are grateful to Bo Ding, Bonacept LLC., San Diego, for analyzing ERRBS data and preparing graphs and Kelly Banks, WCM, for performing gene expression cluster analyses. We are thankful to the laboratory of Jayanta Chaudhuri, MSKCC, for providing tail tips. The Epigenomics Core Facility of Weill Cornell Medical College carried out ERRBS and RNA‐seq. WiCell Cytogenetics Laboratory, Wisconsin, performed G‐banded karyotyping. This study was supported by a contract from the New York State Department of Health to T.E. (NYSTEM C029156)."