Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.

"Conflict of interest The authors have no conflict of interest to declare."

"We thank the members of our laboratory for useful advice. We also thank Dr. Boudewijn MT Burgering (University Medical Center Utrecht, The Netherlands) for the p300 and FOXO mutant vectors. This study was financially supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology (#23390199, #25112708, #25134711, #30253420, #26670604) (MK, HI, MM); a Grant-in-Aid from the Ministry of Health, Labor, and Welfare (#H23-003) (MK, HI, MM); grants from National Institute of Biomedical Innovation (#12-4) (MK, HI, MM) and Osaka University Drug Discovery Funds, Japan (MK, HI, MM); grants from the Kobayashi Cancer Research Foundation (HI), Princess Takamatsu Cancer Research Fund (HI), Takeda Science and Medical Research Foundation (HI), Suzuken Memorial Foundation (MK), Yasuda Medical Foundation (NN), and Pancreas Research Foundation of Japan (KK). MK and HI received partial support from Chugai Co., Ltd., Yakult Honsha Co., Ltd., through institutional endowments. HI received partial support from Merck Co., Ltd., Unitech Co., Ltd., EBM Research Center Inc., and Taiho Therapeutic Co., Ltd. through institutional endowments; those funders had no role in main experimental equipments, supplies expenses, study design, data collection and analysis, decision to publish, or preparation of the manuscript, in this work."