A systematic review of trial-based economic evaluations of internet- and mobile-based interventions for substance use disorders.

"Conflicts of interest : None declared."

"Funding This project has received funding from Horizon 2020 (EU Research and Innovation programme) under grant agreement No 634757. Conflicts of interest: None declared. Key pointsDue to the heterogeneity in types of internet- and mobile-based interventions, sorts of ‘treatment-as-usual’ and targeted conditions, no single and general conclusion about the cost-effectiveness of internet interventions can be presented in this fragmented research field.The economic evaluations included in this systematic review comparing an internet- and mobile-based intervention to a control condition mostly demonstrated favourable cost-effectiveness across varying target conditions.Results of this review are promising and support the notion that employment of internet- and mobile-based interventions might have the potential as cost-effective strategy to scale-up existing evidence-based treatments for substance use disorders."

"Systematic review registration The systematic review has been registered in the PROSPERO database (no. CRD42018099486)."