Digenic inheritance of human primary microcephaly delineates centrosomal and non-centrosomal pathways.

"all variants reported in this manuscript have been submitted to the clinvar database ( https://www ncbi nlm nih gov/clinvar/ ; clinvar accessions scv000998479-scv000998508) 2 5 variants were filtered for quality criteria (pass gatk (depristo et al 2011 ) standard filter read depth >=10) allelic frequency (based on the maximum minor allele frequency found in exac (lek et al 2016 ) 1000 g (thegenomes project consortium 2015 1000) esp6500 ( https://evs gs washington edu/evs/ ; source: dbnsfp2 8) gonl r5 (genome of the netherlands consortium 2014 ) aric5606 ( https://sites cscc unc edu/aric/ ) and our in-house database) and for functional impact (nonsynonymous or splice junction effect using snpeff_effect from snpeff (cingolani et al 2012 )).; all variants reported in this manuscript have been submitted to the clinvar database ( https://www ncbi nlm nih gov/clinvar/ ; clinvar accessions scv000998479-scv000998508)."

"CONFLICT OF INTERESTS The authors declare that there are no conflict of interests."

"We thank Christelle Golzio for guidance in zebrafish phenotyping, and Raphael Helaers for help in variant filtering. We thank all the patients and families for their participation in this study. This work was supported by ERA‐net E‐Rare Euromicro, the Action de Recherche Concertée (ARC) of the Belgian Fédération Wallonie Bruxelles, the Fonds de la Recherche Scientifique FRS‐FNRS Belgium, the Convention Jean Van Damme of the Fonds Erasme and the Fonds de soutien Marguerite‐Marie Delacroix. It was facilitated by the European Reference Network on Rare Congenital Malformations and Rare Intellectual Disability (ERN‐ITHACA; EU Framework Partnership Agreement ID: 3HP‐HP‐FPA ERN‐01‐2016/739516)."