Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population.

"the dna copy number data are available in the european genome-phenome archive (ega; https://www ebi ac uk ) under egas00001002952/egad00001004078."

"CONFLICTS OF INTEREST Guarantor of the article: Gerrit A. Meijer, MD, PhD. Specific author contributions: L.J.W.B. and V.M., contributed equally to this work. L.J.W.B., V.M., E.D., B.M.B., M.v.E., B.C., and G.A.M.: study concept and design. L.J.W.B., V.M., S.M., K.L.J.D., S.T.v.T., E.M.S., T.R.d.W., C.R., and M.J.D.: acquisition of data. L.J.W.B., V.M., and B.C.: interpretation of data. L.J.W.B. and V.M.: drafting of manuscript. All authors: critical revision. L.J.W.B. and V.M.H.C.: statistical analysis. E.J.K. and G.A.M.: obtained funding. B.M.B. and G.A.M.: study supervision. Financial support: This study was performed within the framework of the Center for Translational Molecular Medicine (DeCoDe project, grant 030–101), supported by Exact Sciences Corporation and supported by a SU2C-DCS International Translational Cancer Research Dream Team Grant (SU2C-AACR-DT1415, MEDOCC). Stand Up to Cancer is a program of the Entertainment Industry Foundation administered by the American Association for Cancer Research and the Dutch Cancer Society. The study was further funded by The Netherlands Organisation for Health Research and Development of the Dutch Ministry of Health (ZonMW 120720012 and 121010005) and the Nuts Ohra Foundation (Amsterdam, the Netherlands). Potential competing interests: B.M.B., G.P.L., and M.J.D. are employees and equity holders of Exact Sciences Corporation."

"Financial support: This study was performed within the framework of the Center for Translational Molecular Medicine (DeCoDe project, grant 030–101), supported by Exact Sciences Corporation and supported by a SU2C-DCS International Translational Cancer Research Dream Team Grant (SU2C-AACR-DT1415, MEDOCC). Stand Up to Cancer is a program of the Entertainment Industry Foundation administered by the American Association for Cancer Research and the Dutch Cancer Society. The study was further funded by The Netherlands Organisation for Health Research and Development of the Dutch Ministry of Health (ZonMW 120720012 and 121010005) and the Nuts Ohra Foundation (Amsterdam, the Netherlands)."

"Between June 2009 and July 2010, a total of 6,600 asymptomatic individuals in the regions of Amsterdam and Rotterdam, aged 50–75 years, were randomly selected by the regional municipal administration registrations and invited for primary colonoscopy screening. The protocol of this population-based screening pilot (COlonoscopy or COlonography for Screening [COCOS] trial) has been described in detail previously (). The results on participation and diagnostic yield of this trial have been published (). In short, participation with CT colonography was significantly better than with colonoscopy, but colonoscopy identified significantly more advanced neoplasia per 100 participants (,) than did CT colonography (,). The diagnostic yield for advanced neoplasia per 100 invitees was similar for both strategies (1.5 per 100 invitees for colonoscopy and 2.0 per 100 invitees for CT colonography). The trial was registered in the Dutch Trial Register: NTR1829 (http://www.trialregister.nl). At the time of the trial, the Netherlands did not have a population-based CRC screening program, and invitees were screening-naive. Invitees who had had a full colonic examination in the previous 5 years (complete colonoscopy, CT colonography, and/or double-contrast barium enema) were excluded from the screening trial. Invitees planned for surveillance colonoscopy (personal history of CRC, colonic adenomas, or inflammatory bowel disease) and individuals with end-stage disease and a life expectancy of less than 5 years were also excluded. Ethical approval was obtained from the Dutch National Health Council (2009/03WBO, Hague, the Netherlands)."