Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer.

"the original microarray data are available in a gene expression omnibus database repository submission (gse126856 and gse120181). we detected 405 downregulated genes by mir-8080 in 22rv1 cells which were genes related to metabolisms oxidation-reduction reactions and endoplasmic reticulum (er) stress ( supplementary figure s6a and dataset s1 available at carcinogenesis online).; gene ontology pathway analysis confirmed signaling pathways associated with er were significantly downregulated by mir-8080 ( supplementary figure s6b dataset s2 available at carcinogenesis online).; kyoto encyclopedia of genes and genomes pathway enrichment analysis also suggested mir-8080 induced upregulation of pathways related to the unfolded protein response and downregulation of the er-associated degradation (erad) may result in the induction of er stress-related cell death ( dataset s1-3 available at carcinogenesis online).; of the genes downregulated by mir-8080 71 genes may have possibility to be direct targets of mir-8080 and did not include er stress-related genes ( dataset s4 available at carcinogenesis online).; dataset s1.; dataset s2.; dataset s3.; dataset s4."

"Conflict of interest statement: None declared."

"Funding This work was supported by a Grant-in-Aid for the 3rd Term of a Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare of Japan to ST; a Grant-in-Aid for Research at Nagoya City University to AN-I and a grant from Ono Pharmaceutical Co., Ltd to ST."