Factors influencing adherence in a trial of early introduction of allergenic food.

"Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest."

"The main components of the Enquiring About Tolerance (EAT) study were jointly funded by the UK Food Standards Agency (FSA; contract code T07051) and the Medical Research Council (MRC; grant MC_G1001205). Additionally, we thank the Davis Foundation. The skin-related aspects of the EAT study were supported by the UK National Institute for Health Research (NIHR). C.F. held a National Institute for Health Research Clinician Scientist Award (NIHRCS/01/2008/009). The analyses presented in this article were supported by a subsequent grant from the FSA (contract code FS101178) and the European Union (Integrated Approaches to Food Allergen and Allergy Risk Management [iFAAM], grant agreement no. 312147). The views expressed in this publication are those of the authors and not necessarily those of the FSA, MRC, the National Health Service, the NIHR, the Wellcome Trust, the European Union, or the UK Department of Health."

"One thousand three hundred three 3-month-old infants were recruited from the general population in England and Wales through direct advertising and were enrolled between November 2009 and July 2012. Details of the EAT study methodology have been published elsewhere. Maternal age at enrollment ranged from 19 to 46 years (median, 33 years), and there was no difference in maternal age between study groups. The median age was used as the cutoff for dividing mothers into younger (<33 years) and older (≥33 years) groups. All children were generally well, exclusively breastfed, and born at term (≥37 weeks' gestation). Ethnic origin of the child was based on their parent-defined ethnicity coded by using the classification used in the 2001 UK Census. One thousand one hundred four (84.7%) of the enrolled infants were white, 119 (9.1%) were mixed, and 80 (6.1%) were black, Asian, or Chinese. The trial was registered with the ISRCTN (registration no. 14254740). Ethical approval for the EAT study was provided by St Thomas' Hospital REC (REC reference 08/H0802/93), and informed consent was obtained from the parents of all children enrolled in the study."