Chronic activation of anti-oxidant pathways and iron accumulation in epileptogenic malformations.

"Conflict of interest The authors declare that they have no conflict of interest."

"TSZ, GC, AA, AK and JDM performed the experiments, data collection and analysis. WvH, WGS, PCvR, JCB, SI and EA helped with the selection and collection of human brain tissues and clinical data. NRR and MW collected Tsc1GFAP−/− mouse tissue. EA, EAvV and JDM conceived the study and participated in its design and coordination. TSZ, JDM, EAvV and EA drafted and prepared the manuscript. All authors read, revised and approved the final manuscript. The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007‐2013) under grant agreement no. 602391 (EPISTOP; EA, FJ) and no. 602102 (EPITARGET; EAvV, EA), the Dutch Epilepsy Foundation, project number 16‐05 (EAvV), the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska‐Curie grant agreement no. 642881 (ECMED; AK, EA) and no. 722053 (EU‐GliaPhD; TS, EA) and the United States National Institutes of Health NS056872 (MW)."