Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia.

"Disclosure The authors do not have any conflicts of interest."

"The Dementia Research Center is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation. This work was supported by the NIHR Queen Square Dementia Biomedical Research Unit, the NIHR UCL/H Biomedical Research Center and the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility as well as an Alzheimer's Society grant (AS-PG-16-007). JDR is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1). ZJ is supported by the Department of Health's NIHR Biomedical Research Center's funding scheme. TL is supported by an Alzheimer's Research UK senior fellowship. The Queen Square Brain Bank is supported by the Reta Lila Weston Institute for Neurological Studies and the Medical Research Council. The authors thank Catherine Strand, Robert Courtney, and Geshanthi Hondhamuni at QSBB for the assistance with the brain tissue processing and histology slide preparation."