Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis.

"Conflict of interest The authors declare that they have no conflict of interest."

"This work was supported by the Ministerio de Economía y Competitividad of Spain (SAF2010-15881 AND SAF2013-45784-R), the Junta de Castilla y León (GR100), the Fundación Renal Iñigo Álvarez de Toledo, the Kidney Research Network REDINREN (RD06/0016/0013, RD12/0021/0032 and RD016/0009/0025) and the Instituto de Salud Carlos III (PI16/00460 and co-funded by FEDER). Furthermore, CO-I and EN-G are supported by a contract from the Ministerio de Economía y Competitividad of Spain, and CE-T is supported by a fellowship from the Fundación Miguel Casado San José. We thank Carmelo Bernabéu for his excellent suggestions regarding the design of this work and for revising the manuscript; Elena Llano Cuadra for performing the stable infection of EA.hy926 and 3LL cells; Francisco Sánchez-Madrid for generously giving us the anti-endoglin hybridoma; Jesús García Briñón and Javier Herrero Turrión for helping us with the cryostat and confocal microscope, respectively; and Katie Bentley for generously giving us the patching algorithm."