Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.

"availability of data and materials: the dna methylation data from cd4 + and b cells used in this study together with paired transcriptome data are available in the gene expression omnibus database (accession no gse137634; http://www ncbi nlm nih gov/geo ). availability of data and materials: the dna methylation data from cd4 + and b cells used in this study together with paired transcriptome data are available in the gene expression omnibus database (accession no gse137634"

"Disclosure of potential conflict of interest: Funding for this work came from the Academy of Medical Sciences, the JGW Patterson Foundation, and an unrestricted research grant from Pfizer. It was further supported by the National Institute of Health Research (NIHR) Newcastle Biomedical Research Centre at Newcastle Hospitals Foundation Trust and Newcastle University, the NIHR Manchester Musculoskeletal Biomedical Research Centre, and the British Medical Association (Doris Hillier Award to A.G.P.). Newcastle researchers received infrastructural support via the Versus Arthritis Research into Inflammatory Arthritis Centre. N.T. was supported by a Wellcome Trust clinical training fellowship. N. Nair was funded by an MRC/Versus Arthritis stratified medicine award (grant no. MR/K015346/1), and data generation was supported by Versus Arthritis (grant no. 21754)."

"Funding for this work came from the 10.13039/501100000691Academy of Medical Sciences, the 10.13039/100010089JGW Patterson Foundation and an unrestricted research grant from 10.13039/100004319Pfizer. It was further supported by the 10.13039/501100012295National Institute of Health Research (NIHR) Newcastle Biomedical Research Centre at Newcastle Hospitals Foundation Trust and Newcastle University, the NIHR Manchester Musculoskeletal Biomedical Research Centre and the British Medical Association (BMA; Doris Hillier Award to Dr Pratt). Newcastle researchers received infrastructural support via the Versus Arthritis Research into Inflammatory Arthritis Centre, and are grateful to Mr Ben Hargreaves for administrative support. N.T. was supported by a 10.13039/100004440Wellcome Trust clinical training fellowship. N. Nair’s work was funded by an 10.13039/501100000265MRC/Versus Arthritis stratified medicine award, MATURA (MR/K015346/1); data generation was supported by Versus Arthritis (grant ref 21754), and the authors acknowledge the assistance given by IT Services and the use of the Computational Shared Facility at The University of Manchester. Views expressed are the authors’ and not necessarily those of the National Health Service, the National Institute of Health Research, the Department of Health, JGWP, the British Medical Association, Pfizer, or Versus Arthritis. Disclosure of potential conflict of interest: Funding for this work came from the Academy of Medical Sciences, the JGW Patterson Foundation, and an unrestricted research grant from Pfizer. It was further supported by the National Institute of Health Research (NIHR) Newcastle Biomedical Research Centre at Newcastle Hospitals Foundation Trust and Newcastle University, the NIHR Manchester Musculoskeletal Biomedical Research Centre, and the British Medical Association (Doris Hillier Award to A.G.P.). Newcastle researchers received infrastructural support via the Versus Arthritis Research into Inflammatory Arthritis Centre. N.T. was supported by a Wellcome Trust clinical training fellowship. N. Nair was funded by an MRC/Versus Arthritis stratified medicine award (grant no. MR/K015346/1), and data generation was supported by Versus Arthritis (grant no. 21754)."