Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics.

"Disclosure statement The authors declare that they have no competing interests."

"The Deep and Frequent Phenotyping Study is funded by the 10.13039/501100000265Medical Research Council, United Kingdom and National Institute for Health Research as part of the Dementias Platform UK (MR/N029941/1). JBR is supported by the 10.13039/100010269Wellcome Trust, United Kingdom (103838); Medical Research Council (SUAG/004 RG91365) and National Institute for Health Research Cambridge Biomedical Research Centre. RH is supported by the Medical Research Council (SUAG/010 RG91365). MWW's research is supported by the NIHR Oxford Health Biomedical Research Centre, the Wellcome Trust (106183/Z/14/Z and 203139/Z/16/Z) and the MRC UK MEG Partnership Grant (MR/K005464/1). EK is funded by the Dementias Platform UK and Alzheimer's Research UK (RG94383/RG89702). The authors thank all participants and their families, the PET technicians, radiochemists, the MRI radiographers, and the clinical research nurses for their cooperation and support of this study. They thank Avid radiopharmaceuticals for the provision of [18F]AV-1451 doses and Wellcome Centre for Human Neuroimaging at University College London for their support with MEG scans. The authors thank Dr Rezvan Farahibozorg and Dr Timothy Rittman for useful discussions about the analyses and methods. Ece Kocagoncu: Methodology, Formal analysis, Data curation, Visualization, Writing - original draft. Andrew Quinn: Investigation. Azadeh Firouzian: Investigation, Formal analysis. Elisa Cooper: Investigation. Andrea Greve: Investigation. Roger Gunn: Conceptualization, Methodology. Gary Green: Resources. Mark W. Woolrich: Methodology, Supervision, Writing - review & editing. Richard N. Henson: Methodology, Supervision, Writing - review & editing. Simon Lovestone: Conceptualization, Funding acquisition, Writing - review & editing. James B. Rowe: Methodology, Conceptualization."