Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells.

"Conflict of interest The authors declare no conflict of interest."

"Open Access funding provided by Projekt DEAL. This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Projektnummer 158989968—SFB 900 project C7 and DFG project GE 2145/3-2, and the Knut and Alice Wallenberg Foundation to G.G., by the international Infection Biology Ph.D. program of Hannover Biomedical Research School to R.M., by the German Academic Exchange Service (DAAD) project 91681926 to J.K., by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) to J.P.M (MA 7525/1-1) as part of the Research Unit FOR 2518, DynIon; project P4) and by the DFG—Projektnummer 158989968—SFB 900 project B10 to L.J.S. The authors gratefully acknowledge the computing time granted through JARA on the supercomputer JURECA at Forschungszentrum Jülich. We thank Charles M. Rice for Huh-7.5 cells, Ralf Bartenschlager for HCV infectious clones and Jens Bukh for the pan-genotypic panel of JFH-1-based chimeras. The data presented were acquired as part of a Master thesis within the AMIBA program. We are grateful to T.F. Schulz for the constant support."