Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory.

"The authors thank Anna Akhmanova, Gloria Lee, Sangmok Lee, and Thomas B. Shea, for generous donations of cDNA expression plasmids, Friedrich Propst for anti‐MAP1A LC and anti‐MAP1B LC antibodies, Maximilian Tschol for valuable help in collecting data. The authors also thank Maria J. Castañón for constructive criticism at many stages of the project. Behavioural assessments of mice were performed at the Preclinical Phenotyping Facility at Vienna Biocenter Core Facilities (VBCF), member of Vienna Biocenter (VBC), Austria. The authors acknowledge the support of former and present facility heads Mumna al Banchaabouchi (deceased 2018) and Sylvia Badurek; particularly the authors thank SB for guidance through the data of a project done under her predecessor and for valuable feedback. GW was supported by the Austrian Science Research Fund (FWF) Grants P23729‐B11 and I1207‐B24, the latter being part of the Multilocation Deutsche Forschungsgemeinschaft (DFG)‐Research Unit 1228 Molecular Pathogenesis of Myofibrillar Myopathies. LW was supported by Austrian Science Research Fund (FWF) Grant P31541‐B27. JJ, MP and RZ were supported by the Research Agency of Slovenia (core research program # P3 0310) and EuroCellNet COST Action (CA15214)."