Pannexin-1 channel "fuels" by releasing ATP from bone marrow cells a state of sterile inflammation required for optimal mobilization and homing of hematopoietic stem cells.

"Conflict of interest Monika Cymer declares that she has no conflict of interest. Katarzyna Brzezniakiewicz-Janus declares that she has no conflict of interest. Kamila Bujko declares that she has no conflict of interest. Arjun Thapa declares that he has no conflict of interest. Janina Ratajczak declares that she has no conflict of interest. Krzysztof Anusz declares that he has no conflict of interest. Michał Tracz declares that he has no conflict of interest. Agnieszka Jackowska-Tracz declares that she has no conflict of interest. Mariusz Z. Ratajczak declares that he has no conflict of interest. Mateusz Adamiak declares that she has no conflict of interest."

"Funding information This work was supported by NIH grants 2R01 DK074720, the Stella and Henry Endowment, and the OPUS grant DEC-2016/23/B/NZ3/03157 to MZR. AT was supported by NIH T32 HL134644 Training Grant to MZR."