Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease.

"Disclosure statement AB and AR are shareholders in the company GliaGenesis. The authors declare no other conflicts."

"Supported by grants from the BBSRC (AB, AR, Grant Number BB/M029379/1), MRC (AB, MP, Grant Number MR/P025811/1), Alzheimer's Research UK (DG, AB, Grant Number PG2014B-2), EU Marie Curie Framework 7 (AB, AV, IV), University of Portsmouth PhD Program (AB, ICR), Spanish Ministerio de Economía y Competitividad, RETOS Colaboración (JJR, Grant Number RTC-2015-3542-1, co-financed by FEDER). Ilaria Vanzulli: Formal analysis, Investigation, Methodology, Writing - original draft. Maria Papanikolaou: Formal analysis, Investigation, Methodology, Validation. Irene Chacon De-La-Rocha: Investigation, Methodology, Validation. Francesca Pieropan: Investigation, Methodology, Validation. Andrea D. Rivera: Investigation. Diego Gomez-Nicola: Writing - review & editing. Alexei Verkhratsky: Conceptualization, Writing - review & editing. José Julio Rodríguez: Conceptualization, Resources, Software, Writing - review & editing. Arthur M. Butt: Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing."