An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.

"We thank the AddNeuroMed cohort and the participants who made this research possible. The AddNeuroMed data are from a public-private partnership supported by EFPIA companies and SMEs as part of InnoMed (Innovative Medicines in Europe), an Integrated Project funded by the European Union of the Sixth Framework program priority FP6 2004-LIFESCIHEALTH-5. Clinical leads responsible for data collection are Iwona Kłoszewska (Lodz), Simon Lovestone (London), Patrizia Mecocci (Perugia), Hilkka Soininen (Kuopio), Magda Tsolaki (Thessaloniki), and Bruno Vellas (Toulouse); the imaging leads are Andy Simmons (London), Lars-Olad Wahlund (Stockholm), and Christian Spenger (Zurich); and the bioinformatics leads are Richard Dobson (London) and Stephen Newhouse (London). This work was further supported by The National Institute for Health Research at the University College London Hospitals Biomedical Research Centre, the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, and Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation and Wellcome Trust. Support for the current study was provided by a major project grant from the 10.13039/501100000320Alzheimer's Society, United Kingdom (AS-PG-14–038) to KL, a project grant from the 10.13039/501100000265Medical Research Council (MRC), United Kingdom (MR/N027973/1) to KL as part of the Joint Programme—Neurodegenerative Disease Research (JPND) initiative for the EPI-AD consortium, an 10.13039/100000002NIH, United States, R01 grant (AG036039) to JM, an Equipment Grant from Alzheimer's Research UK (ART-EG2010A-2) to JM, a PhD studentship from the GW4 MRC BioMed DTP (United Kingdom) for JAYR, and an Alzheimer's Research UK South West Network Centre pump priming award to JAYR. Janou A.Y. Roubroeks: Conceptualization, Methodology, Software, Writing - original draft, Writing - review & editing, Formal analysis, Investigation. Adam R. Smith: Investigation, Validation, Writing - review & editing. Rebecca G. Smith: Methodology, Writing - review & editing. Ehsan Pishva: Methodology, Formal analysis, Writing - review & editing. Zina Ibrahim: Formal analysis, Resources. Martina Sattlecker: Formal analysis, Writing - review & editing, Resources. Eilis J. Hannon: Methodology, Writing - review & editing. Iwona Kłoszewska: Resources. Patrizia Mecocci: Resources. Hilkka Soininen: Resources. Magda Tsolaki: Writing - review & editing, Resources. Bruno Vellas: Resources. Lars-Olof Wahlund: Writing - review & editing, Resources. Dag Aarsland: Writing - review & editing, Resources. Petroula Proitsi: Resources. Angela Hodges: Resources. Simon Lovestone: Writing - review & editing, Resources. Stephen J. Newhouse: Resources. Richard J.B. Dobson: Writing - review & editing, Resources. Jonathan Mill: Funding acquisition, Writing - review & editing, Resources. Daniël L.A. van den Hove: Funding acquisition, Conceptualization, Writing - original draft, Writing - review & editing, Supervision, Project administration. Katie Lunnon: Funding acquisition, Conceptualization, Writing - original draft, Writing - review & editing, Supervision, Project administration."