Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer.

"Conflicts of interest: The authors disclose no conflicts."

"The authors thank all study participants, the CCFRC and staff, and the Dutch Parelsnoer Institute Biobank Hereditary Colorectal Cancer for their contributions to this project. Furthermore, we would like to thank Robbert Weren, Eveline Kamping, M. Elisa Vink-Börger, Riki Willems, Christian Gillissen, Peggy Manders, Dina Ruano, Ruud van der Breggen, Marina Ventayol, Sanne ten Broeke, Allyson Templeton, Maggie Angelakos, members of the Colorectal Oncogenomics Group, Sharelle Joseland, Susan Preston, Julia Como, Thomas Green, Magda Kloc, and Chris Cotsopoulos for their contributions to this project. The author(s) would further like to acknowledge networking support by the Cooperation in Science and Technology Action CA17118, supported by the European Cooperation in Science and Technology. Funding This study was funded by research grants from the Dutch Cancer Society (KUN2015-7740), the Dutch Digestive Foundation (MLDS FP13-13 to Tom van Wezel), Instituto de Salud Carlos III and European Regional Development Fund (ERDF) (PI14/00230 to Clara Ruiz Ponte) and by grant UM1 CA167551 from the National Cancer Institute and through cooperative agreements with the following Colon Cancer Family Registry Cohort (CCFRC) sites: Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), and Seattle Colorectal Cancer Family Registry (U01/U24 CA074794). Daniel B. Buchanan is a University of Melbourne Research at the Melbourne Accelerator Program (R@MAP), principal research fellow, and National Health and Medical Research Council (NHMRC) R.D. Wright Career Development Fellow. Abiram Ragunathan is a Melbourne Genomics Health Alliance Fellow."

"This study was funded by research grants from the Dutch Cancer Society (KUN2015-7740), the Dutch Digestive Foundation (MLDS FP13-13 to Tom van Wezel), Instituto de Salud Carlos III and European Regional Development Fund (ERDF) (PI14/00230 to Clara Ruiz Ponte) and by grant UM1 CA167551 from the National Cancer Institute and through cooperative agreements with the following Colon Cancer Family Registry Cohort (CCFRC) sites: Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), and Seattle Colorectal Cancer Family Registry (U01/U24 CA074794). Daniel B. Buchanan is a University of Melbourne Research at the Melbourne Accelerator Program (R@MAP), principal research fellow, and National Health and Medical Research Council (NHMRC) R.D. Wright Career Development Fellow. Abiram Ragunathan is a Melbourne Genomics Health Alliance Fellow."