Temporal Trend of Age at Diagnosis in Hypertrophic Cardiomyopathy: An Analysis of the International Sarcomeric Human Cardiomyopathy Registry.

"Disclosures Drs Day, Ho, Olivotto, and Ashley receive research support from Myokardia, Inc. The other authors report no conflicts related to the present work."

"Sources of Funding Funding for SHaRe has been provided through an unrestricted research grant from Myokardia, Inc, a startup company that is developing therapeutics that target the sarcomere. MyoKardia, Inc, had no role in approving the content of this manuscript. Dr Day is supported by funding from the National Institutes of Health (R01 GRANT11572784), the American Heart Association (grant in aid), and the Taubman Medical Institute (University of Michigan). Dr Ware is supported by the Wellcome Trust (107469/Z/15/Z) and the Medical Research Council (United Kingdom). Dr Ho is supported by funding from the National Institutes of Health (1P50HL112349 and 1U01HL117006). Dr Olivotto was supported by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement no. 777204: SILICOFCM—In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy; by the Italian Ministry of Health (left ventricular hypertrophy in aortic valve disease and hypertrophic cardiomyopathy): genetic basis, biophysical correlates, and viral therapy models (RF-2013-02356787), and NET-2011-02347173 (mechanisms and treatment of coronary microvascular dysfunction in patients with genetic or secondary left ventricular hypertrophy) and by the Ente Cassa di Risparmio di Firenze (bando 2016) juvenile sudden cardiac death: just know and treat."