The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations.

Publication Year: 2020

DOI:
10.1016/j.bcp.2020.114215

PMCID:
PMC7474874

PMID:
32905794

Journal Information

Full Title: Biochem Pharmacol

Abbreviation: Biochem Pharmacol

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Biochemistry

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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Evidence found in paper:

"Conflict of interest The authors declare no conflict of interest."

Evidence found in paper:

"AcknowledgementsWe would like to acknowledge and thank Mr. Gunnar Glasser (Department of Physical Chemistry of Polymers; Max Planck Institute for Polymer Research; Mainz – Germany) for his expert electron microscopy contributions. W.E.G. M. is the holder of an ERC Advanced Investigator Grant (no. 268476). In addition, W.E.G. M. has obtained three ERC-PoC grants (Si-Bone, no. 324564; MorphoVES-PoC, no. 662486; and ArthroDUR, no. 767234)."

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Last Updated: Aug 05, 2025