Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort.

"Disclosure of potential conflict of interest: P. Nicoletti is an employee of Sema4, a Mount Sinai venture. M.R. Nelson was an employee of GlaxoSmithKline at the time the work was undertaken. M. Pirmohamed receives research funding from various organizations including the MRC, National Institute for Health Research, European Union Commission, and Health Education England. He has also received partnership funding for the following: MRC Clinical Pharmacology Training Scheme (cofunded by MRC and Roche, UCB, Eli Lilly, and Novartis); a PhD studentship jointly funded by Engineering and Physical Sciences Research Council, and AstraZeneca; and grant funding from Vistagen Therapeutics. He also has unrestricted educational grant support for the UK Pharmacogenetics and Stratified Medicine Network from Bristol Myers Squibb and UCB. He has developed an HLA genotyping panel with MC Diagnostics, but does not benefit financially from this. None of the funding declared above has been used for the current paper. The rest of the authors declare that they have no relevant conflicts of interest."

"This work was supported by the International Serious Adverse Events Consortium (iSAEC). The iSAEC is a nonprofit organization dedicated to identifying and validating DNA variants useful in predicting the risk of drug-related serious adverse events. The iSAEC brings together the pharmaceutical industry, regulatory authorities, and academic centers to address clinical and scientific issues associated with the genetics of drug-related serious adverse events. The iSAEC’s funding members included: Abbott, Amgen, AstraZeneca, Daiichi Sankyo, GlaxoSmithKline, Merck, Novartis, Pfizer, Takeda, and the Wellcome Trust. M.P. is a National Institute for Health Research Senior Investigator. M.P. and D.F.C. thank the Medical Research Council (MRC) Centre for Drug Safety Science for support (MR/L006758/1). P.N. was supported by the iSAEC. E.J.P. receives funding from the 10.13039/100000002National Institutes of Health (grants 1P50GM115305-01, R21AI139021, R34AI136815, and 1 R01 HG010863-01) and the 10.13039/501100000925National Health and Medical Research Council of Australia. The views expressed are those of the author(s) and not of any of their funders. The funders played no role in the analysis of the data and interpretation of the findings. Disclosure of potential conflict of interest: P. Nicoletti is an employee of Sema4, a Mount Sinai venture. M.R. Nelson was an employee of GlaxoSmithKline at the time the work was undertaken. M. Pirmohamed receives research funding from various organizations including the MRC, National Institute for Health Research, European Union Commission, and Health Education England. He has also received partnership funding for the following: MRC Clinical Pharmacology Training Scheme (cofunded by MRC and Roche, UCB, Eli Lilly, and Novartis); a PhD studentship jointly funded by Engineering and Physical Sciences Research Council, and AstraZeneca; and grant funding from Vistagen Therapeutics. He also has unrestricted educational grant support for the UK Pharmacogenetics and Stratified Medicine Network from Bristol Myers Squibb and UCB. He has developed an HLA genotyping panel with MC Diagnostics, but does not benefit financially from this. None of the funding declared above has been used for the current paper. The rest of the authors declare that they have no relevant conflicts of interest."