The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators.

"Declaration of Competing Interest TB and AO provide consultancy services to Phytecs Inc. (TB) and Botanix Pharmaceuticals Ltd. (AO). TV is co-inventor on patents entitled “Treatment of pain” derived from WO2012149614, and his lab has received research funding for pain-related research from industrial parties. Botanix Pharmaceuticals Ltd, Phytecs Inc., and the founding sponsors had no role in conceiving the study, designing the experiments, writing of the manuscript, or in the decision to publish it. Other authors declare no conflict of interest."

"The presented work was supported by research grants of the National Research, Development and Innovation Office (K_120187, PD_121360, PD-134791, FK_125055, GINOP-2.3.2-15-2016-00015, EFOP-3.6.3-VEKOP-16-2017-00009, EFOP-3.6.1-16-2016-00022). The work of AO, and BIT was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. B. I. T. was also supported by the New National Excellence Program of the Ministry for Innovation and Technology (ÚNKP-20-5-DE-422). The work of NK and TR was supported by NIH grants NS055159, GM093290 and GM131048 to T.R. Research in the lab of T.V. is supported by grants from the VIB, the KU Leuven Research Council, the Research Foundation-Flanders (FWO G0B7620N to T.V. and G084515N and G0B1819N to J.V.), the Belgian Foundation Against Cancer and the Queen Elisabeth Medical Foundation for Neurosciences. Balázs Kelemen: Conceptualization, Investigation, Formal analysis, Writing - original draft, Writing - review & editing. Silvia Pinto: Conceptualization, Investigation, Formal analysis. Nawoo Kim: Investigation, Formal analysis, Writing - original draft. Erika Lisztes: Investigation, Writing - original draft. Martin Hanyicska:. Anita Vladár: Investigation, Writing - original draft. Attila Oláh: Investigation, Formal analysis, Writing - original draft. Zsófia Pénzes: Investigation, Writing - original draft. Brian Shu: Investigation, Formal analysis. Joris Vriens: Formal analysis, Writing - original draft, Writing - review & editing. Tamás Bíró: Funding acquisition, Formal analysis, Writing -original draft, Writing - review & editing. Tibor Rohács: Formal analysis, Writing - original draft, Writing - review & editing. Thomas Voets: Funding acquisition, Conceptualization, Formal analysis, Writing -original draft, Writing - review & editing. Balázs István Tóth: Conceptualization, Funding acquisition, Supervision, Project administration, Writing - original draft, Writing - review & editing."