Efficacy of therapeutic plasma exchange in the treatment of penn class 3 and 4 cytokine release syndrome complicating COVID-19.

"Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: W. Jeffery Edenfield serves as a consultant for Chimerix, Inc., unrelated to the submitted work. The remaining authors have disclosed that they do not have any conflicts of interest."

"Source of funding The funders of the study had no role in the study design, data collection, data analysis, or writing of the manuscript. Terumo BCT, Inc. provided the disposable apheresis exchange kits. Prisma Health Office of Philanthropy and Partnership assisted in securing funding for the laboratory analysis. All authors had full access to all study data and had final responsibility for the decision to submit the manuscript for publication. W. Jeffery Edenfield serves as a consultant for Chimerix, Inc., unrelated to the submitted work. The remaining authors have disclosed that they do not have any conflicts of interest."

"Registration: ClinicalTrials.gov NCT04374149."