Tumour Necrosis Factor Alpha-induced Protein 3 Negatively Regulates Cutibacterium acnes-induced Innate Immune Events in Epidermal Keratinocytes.

"the dermal part of the biopsies was in contact with dmem f12 liquid culture medium (lonza basel switzerland) supplemented with 10% fbs (euroclone milan italy) lacking ab/am tnfaip3 gene expression was analysed using publicly available microarray data from the geo profile database (gds2478 datasets id: 33444972) which compares the total rna content of healthy skin ( n = 6) with lesional ( n = 6) and non-lesional ( n = 6) samples from patients with acne ( ) tlr1/2 (pam3csk4 5 ?; in order to determine whether tnfaip3 levels differ in control individuals and lesional and non-lesional skin samples from patients with acne the current study compared publicly available microarray data in the geo profile database (id: 33444972) and found that in patients mrna expression of tnfaip3 increases significantly in papules compared with non-lesional skin samples from the same patients."

"The authors have no conflicts of interest to declare."

"The authors thank Tanácsné Bajkán Andrea for her excellent technical assistance and Shannon Frances for language editing. This work was supported by the GINOP-2.3.2-15-2016-00015 and OTKA NK105369 research grants. The project has received funding from the EU’s Horizon 2020 research and innovation programme under grant agreement (number 739593). KS is a recipient of the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. KS was supported by the UNKP-18-4. EL was supported by the UNKP-18-3 of New National Excellence Program of the Ministry of Human Capacities. KS was supported by the ÚNKP-19-4. EL was supported by the ÚNKP-19-3 of New National Excellence Program of the Ministry for Innovation and Technology. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript."