Effects of nasal high flow on nocturnal hypercapnia, sleep, and sympathovagal balance in patients with neuromuscular disorders.

"Conflict of interest JS is supported by the Else-Kröner-Fresenius Stiftung (Grant SP A109) for this work, and by Kommission für Innovative Medizinische Forschung an der Medizinischen Fakultät Muenster (IMF Grant SP 11 18 15), by Deutsche Herzstiftung (DHS Grant S/01/19) and by young investigator research support from Scuola Superiore Sant’Anna Pisa (Curriculum Ph.D. in Translational Medicine) and has received travel grants and lecture honoraria from Boehringer Ingelheim and Chiesi (all) outside the present work. MB is supported by Sanofi Genzyme outside this work. MB and PY have received speaker honoraria and travel grants from Sanofi Genzyme and Löwenstein Medical. MD reports to have received travel grants and/or speaking fees and/or fees for consulting from Actelion, Astra Zeneca, Bayer, Berlin Chemie, Boehringer, Chiesi, Hamilton, Heinen und Löwenstein, Intermune, Linde, Novartis, Pfizer, Philips Respironics, ResMed, Roche and Weinmann. AM, CT, NS, HS, AH and AB declare no conflicts of interest in the context of this paper."

"Funding Open Access funding enabled and organized by Projekt DEAL. This study was supported Löwenstein Medical. The funders had no role in study design, data collection, data analysis or preparation of the manuscript."

"Adult patients with NH due to genetically proven NMD were consecutively recruited from our academic sleep laboratory from April 2018 to August 2019. Inclusion criteria comprised ongoing NIV for less than 5 years, NIV use only during nocturnal sleep and no vital dependence on NIV. Diagnosis of NH and NIV had to be established in our own institution before in order to warrant reliability of clinical and baseline respiratory data. The study protocol conformed to the 1975 Declaration of Helsinki and was approved by the local authorities (Ethikkommission der Ärztekammer Westfalen Lippe und der Medizinischen Fakultät der Westfälischen Wilhelms-Universität Münster; Az. 2017-668-f-S). All subjects gave written informed consent to participate in the study. The project was registered under the German Clinical Trials Registry (drks.de Identifier: DRKS00013903 and DRKS00013905)."