Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

"Disclosure statement Authors declare no conflicts related to this study. Unrelated to this work, JOB has received honoraria for work as DSMB chair or member for TauRx, Axon, Eisai; has acted as a consultant for Lilly; and has received honorarium for talks from GE Healthcare and research support from Alliance Medical."

"Funding: Research grants from the UK Alzheimer's Society, the US Alzheimer's Association and philanthropic donations. This work was funded by a grant for the PREVENT-Dementia program from the UK Alzheimer's Society (grant numbers 178 and 264), and the PREVENT-Dementia study is also supported by the US Alzheimer's Association (grant number TriBEKa-17–519007) and philanthropic donations. AL is supported by the Lee Kuan Yew Fitzwilliam PhD Scholarship and the Tan Kah Kee Postgraduate Scholarship. EM is supported by Alzheimer's Society Junior Research Fellowship (RG 9611). JDS is a Wellcome clinical PhD fellow funded on grant 203914/Z/16/Z to the Universities of Manchester, Leeds, Newcastle and Sheffield. LS is supported by the Cambridge NIHR Biomedical Research Center (BRC) and Alzheimer's Research UK (ARUK-SRF2017B-1). HSM is supported by an NIHR Senior Investigator award. JOB and HSM receive infrastructural support from the Cambridge NIHR BRC."