MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.

"CONFLICT OF INTEREST The authors declare that they have no conflict of interest. AUTHOR CONTRIBUTION Conceição Bettencourt contributed to the design of the study, experimental work, analysis and interpretation of data, and drafted the manuscript; Yasuo Miki contributed to the experimental work, and revised clinical and pathological data; Ignazio S. Piras and Rohan de Silva contributed to the analysis and interpretation of data; Sandrine C. Foti and Joshua S. Talboom contributed to the generation of the data; Thomas T. Warner and Tamas Revesz revised clinical and/or pathological data; Emmanuelle Viré, Robert Balazs and Tammaryn Lashley contributed for the design of the work, and interpretation of the data; Matt J. Huentelman and Janice L. Holton made substantial contributions to the conception and supervision of the work. All authors have critically revised the manuscript and approved the submitted version."

"We would like to dedicate this study to the memory of Professor Robert Balazs, who sadly left us while the manuscript was under review. The authors would like to thank Ms Gaganjit Kaur Madhan (MSc) for sample processing and UCL Genomics centre for advice and processing of the EPIC arrays. The Queen Square Brain Bank (QSBB) is supported by the Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology. The authors would like to thank all QSBB staff for their technical support. CB is supported by the Multiple System Atrophy Trust, the British Neuropathological Society and an Alzheimer's Research UK Research Fellowship. RdS is supported by Karin & Sten Mortstedt CBD Solutions and the Reta Lila Weston Trust. TR is supported by Karin & Sten Mortstedt CBD Solutions. TL is supported by an Alzheimer's Research UK Senior Fellowship. TTW is supported by the Reta Lila Weston Trust and the MRC (N013255/1). JLH is supported by the Multiple System Atrophy Trust; the Multiple System Atrophy Coalition; Fund Sophia, managed by the King Baudouin Foundation and Karin & Sten Mortstedt CBD Solutions. This work was supported in part by the NIH National Institute of Neurological Disorders and Stroke grant R21 NS093222 awarded to MJH. This research was also supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre."