Space-time logic of liver gene expression at sub-lobular scale.

"data availability scrna-seq data all scrna-seq data is deposited in geo with accession code gse145197. reconstructed gene profiles reconstructed spatio-temporal gene profiles are available as matlab files at https://github com/naef-lab/circadian-zonation web-application the whole dataset of gene profiles along with the analysis is available online as a web-application at the url https://czviz epfl ch/ .; code availability the code for fitting the mixed-effects models and generating the main figures is available at https://github com/naef-lab/circadian-zonation details regarding the statistics software and data are provided in the reporting summary. data availability scrna-seq data all scrna-seq data is deposited in geo with accession code gse145197"

"reconstructed gene profiles reconstructed spatio-temporal gene profiles are available as matlab files at https://github com/naef-lab/circadian-zonation web-application the whole dataset of gene profiles along with the analysis is available online as a web-application at the url https://czviz epfl ch/ .; code availability the code for fitting the mixed-effects models and generating the main figures is available at https://github com/naef-lab/circadian-zonation details regarding the statistics software and data are provided in the reporting summary."

"Competing interests: The authors declare no competing interests."

"We thank Daniel Mauvoisin for assistance with the animal work, Cédric Gobet for bioinformatics advice, and the EPFL BIOP facility for advice with microscopy. This work was supported by the Rothschild Caesarea Foundation’ fund managed by Weizmann Institute and EPFL, a Swiss National Science Foundation Grant 310030_173079 (to F. Naef), and the EPFL. S. Itzkovitz is supported by the Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics, The Leir Charitable Foundations, Richard Jakubskind Laboratory of Systems Biology, Cymerman-Jakubskind Prize, The Lord Sieff of Brimpton Memorial Fund, the Wolfson Foundation SCG, the Wolfson Family Charitable Trust, Edmond de Rothschild Foundations, the I-CORE program of the Planning and Budgeting Committee and the Israel Science Foundation (grants 1902/12 and 1796/12, the Israel Science Foundation grant no. 1486/16, the Chan Zuckerberg Initiative grant no. CZF2019-002434, the Broad Institute-Israel Science Foundation grant no. 2615/18, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 768956, the Bert L. and N. Kuggie Vallee Foundation, and the Howard Hughes Medical Institute (HHMI) international research scholar award."