Cannabidiol as a treatment for craving and relapse in individuals with cocaine use disorder: a randomized placebo-controlled trial.

"Declaration of interests The Canadian Institutes of Health Research funded this study. The investigational product was provided by Insys Therapeutics. D.J.A. holds a scholar award from the Fonds de recherche du Québec en Santé. J.B. receives financial support from AbbVie and Gilead Sciences for work outside of this study. V.M.P., S.B., P.C., S.D., G.G. and E.S. report no financial relationship with commercial interests. The funder of the study or Insys Therapeutics had no role in study design, data collection, data analysis, data interpretation or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication."

"Violaine Mongeau‐Pérusse: Formal analysis; writing ‐ original draft. Suzanne Brissette: Funding acquisition; investigation; methodology; writing ‐ review and editing. Julie Bruneau: Conceptualization; funding acquisition; methodology; writing ‐ review and editing. Patricia Conrod: Funding acquisition; methodology; writing ‐ review and editing. Simon Dubreucq: Investigation; methodology; writing ‐ review and editing. Guillaume Gazil: Data curation; formal analysis; writing ‐ review and editing. Emmanuel Stip: Funding acquisition; methodology; writing ‐ review and editing. Didier Jutras‐Aswad: Conceptualization; formal analysis; funding acquisition; investigation; methodology; project administration; supervision; writing ‐ original draft."

"This study was registered with ClinicalTrials.gov, NCT02559167. An independent data safety and monitoring board was assembled to ensure human safety and advise on study conduct. Analyses were performed using the SAS version 9.4 software (SAS Institute, Cary, NC, USA). For all analyses, the level of significance was 5% except for the primary analysis where a Bonferroni‐corrected value of 2.5% was used to account for the primary outcomes’ multiplicity. Demographic and baseline characteristics of randomized participants are reported using descriptive statistics."