In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

"Disclosures James B Rowe serves as an associate editor to Brain and is a nonremunerated trustee of the Guarantors of Brain, Darwin College and the PSP Association (UK). He provides consultancy to Asceneuron, Biogen, UCB, Althira, Astex, SVHealth and has research grants from AZ-Medimmune, Janssen, Lilly as industry partners in the Dementias Platform UK. John T. O'Brien has no conflicts related to this study; unrelated to this work he has received honoraria for work as DSMB chair or member for TauRx, Axon, Eisai, has acted as a consultant for Roche, has received research support from Alliance Medical and Merck. The data contained in the manuscript being submitted have not been previously published, have not been submitted elsewhere and will not be submitted elsewhere while under consideration at Neurobiology of Aging. All authors have reviewed and approved the submission of the data. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Declaration of interests James B Rowe serves as an associate editor to Brain and is a nonremunerated trustee of the Guarantors of Brain, Darwin College and the PSP-RS Association (UK). He provides consultancy to Asceneuron, Biogen, UCB, Althira, Astex, SVHealth and has research grants from AZ-Medimmune, Janssen, Lilly as industry partners in the Dementias Platform UK. John T. O'Brien has no conflicts related to this study; unrelated to this work he has received honoraria for work as DSMB chair or member for TauRx, Axon, Eisai, has acted as a consultant for Roche, has received research support from Alliance Medical and Merck. TR has received honoraria from Biogen, unrelated to this work."

"Funding The study was funded by the Cambridge University Centre for Parkinson-Plus (RG95450); the National Institute for Health Research Cambridge Biomedical Research Centre (146281; BRC-1215-20014); the Wellcome Trust (103838) and the Association of British Neurologists, Patrick Berthoud Charitable Trust (NH: RG99368) and Medical Research Council (SUAG 051/G101400). EM is supported by Alzheimer's Society Junior Research Fellowship (443 AS JF 18017). RRG is supported by the Guarantors of Brain Fellowship (RNAG/474). AL is supported by the Lee Kuan Yew Fitzwilliam Scholarship and the Tan Kah Kee Scholarship."