Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children.

"Disclosure of potential conflict of interest: A. F. Santos reports grants and personal fees from Medical Research Council (grants nos. MR/T032081/1, MR/M008517/1, G090218); grants from Asthma UK (G1000758) and the National Institute for Health Research through the Biomedical Research Centre award to Guy’s and St Thomas’ NHS Foundation Trust, during the conduct of the study; grants from Immune Tolerance Network/National Institute of Allergy and Infectious Diseases, National Institutes of Health, Asthma UK and Food Allergy Research and Education (FARE); personal fees from Thermo Scientific, Nutricia, Infomed, Novartis, Allergy Therapeutics, and Buhlmann, as well as research support from Buhlmann and Thermo Fisher Scientific through a collaboration agreement with King’s College London. The rest of the authors declare that they have no relevant conflicts of interest."

"We thank Professor George Du Toit, Dr Suzana Radulovic, and the Paediatric Allergy Team at the Evelina London Children’s Hospital for their effort in recruiting participants and collecting samples to the study, and acknowledge support by the UK National Institute for Health Research comprehensive Biomedical Research Centre award to Guy’s and St Thomas’ National Health Service (NHS) Foundation Trust, in partnership with King’s College London and King’s College Hospital NHS Foundation Trust. This work was supported by the 10.13039/501100000265Medical Research Council (MRC Clinician Scientist FellowshipMR/M008517/1, MRC Centenary Early Career Award, and MRC Clinical Research Training Fellowship no. G0902018 awarded to A.F.S.), 10.13039/501100000362Asthma UK (grant no. AUK-BC-2015-01), and the UK National Institute for Health Research comprehensive 10.13039/100014461Biomedical Research Centre award to Guy’s and St Thomas’ National Health Service (NHS) Foundation Trust, in partnership with King’s College London and King’s College Hospital NHS Foundation Trust. Disclosure of potential conflict of interest: A. F. Santos reports grants and personal fees from Medical Research Council (grants nos. MR/T032081/1, MR/M008517/1, G090218); grants from Asthma UK (G1000758) and the National Institute for Health Research through the Biomedical Research Centre award to Guy’s and St Thomas’ NHS Foundation Trust, during the conduct of the study; grants from Immune Tolerance Network/National Institute of Allergy and Infectious Diseases, National Institutes of Health, Asthma UK and Food Allergy Research and Education (FARE); personal fees from Thermo Scientific, Nutricia, Infomed, Novartis, Allergy Therapeutics, and Buhlmann, as well as research support from Buhlmann and Thermo Fisher Scientific through a collaboration agreement with King’s College London. The rest of the authors declare that they have no relevant conflicts of interest."