Neurometabolite mapping highlights elevated myo-inositol profiles within the developing brain in down syndrome.

"Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by the 10.13039/501100000265Medical Research Council [MR/K006355/1 and MR/LO11530/1]; 10.13039/501100000833Rosetrees Trust [A1563], Sparks and Great Ormond Street Hospital Children's Charity [V5318]. We also gratefully acknowledge financial support from the 10.13039/100010269Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z], the 10.13039/501100000265Medical Research Council [MR/S025065/1] the 10.13039/501100000272National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) based at Guy's and St Thomas' NHS Foundation Trust and King's College London and supported by the NIHR Clinical Research Facility (CRF) at Guy's and St Thomas'. The Brain Imaging in Babies (BIBS) team additionally acknowledge support from EU-AIMS – a European Innovative Medicines Initiative; and infrastructure support from the 10.13039/501100000272National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health."