Novel Trial Design: CHIEF-HF.

"Disclosures Dr Spertus is the principal investigator of grants from National Institutes of Health (NIH), Abbott Vascular, and the American College of Cardiology Foundation; is a consultant to Janssen, Novartis, Amgen, Myokardia, AstraZeneca, Bayer, and Merck; serves on the Scientific Advisory Board of United Healthcare and the Board of Directors for Blue Cross Blue Shield of Kansas City; owns the copyright to the Kansas City Cardiomyopathy Questionnaire (KCCQ), Seattle Angina Questionnaire and Peripheral Artery Questionnaire; and has an equity interest in Health Outcomes Sciences. Dr Butler is a consultant to Abbott, Adrenomed, Arena Pharma, Array, Amgen, Applied Therapeutics, Astra Zeneca, Bayer, BerlinCures, Boehringer Ingelheim, Corvia, Cardior, CVRx, Eli Lilly, FIRE1, Foundry, G3 Pharma, Imbria, Impulse Dynamics, Innolife, Janssen, LivaNova, Luitpold, Medtronic, Merck, Novartis, Novo Nordisk, Relypsa, Roche, SC Pharma, Sanofi, Sequana Medical, V-Wave Limited, Vifor. Dr Lingvay has received research funding, advisory/consulting fees and/or other support from Novo Nordisk, Eli Lilly, Sanofi, Astra Zeneca, Boehringer Ingelheim, Janssen, Intercept, Intarcia, TARGETPharma, Merck, Pfizer, Novartis, GI Dynamics, Mylan, Mannkind, Valeritas, Zealand Pharma. Dr Lanfear has received research grants from National Heart, Lung, and Blood Institute (NHLBI), Amgen, Bayer, Critical Diagnostics, and Janssen; has participated in collaborative research with Somalogic; is a consultant for Amgen, Janssen (CHIEF Steering Committee), Ortho Diagnostics, and Duke Clinical Research Institute (Novartis). Dr Abbate has received research grant support from Janssen; is a consultant to Janssen. Dr Kosiborod has received research grants from AstraZeneca and Boehringer Ingelheim; is a consultant and/or advisory board member for Amarin, Applied Therapeutics, AstraZeneca, Amgen, Bayer, Boehringer Ingelheim, Janssen, Eli Lilly, Merck (Diabetes), Novartis, Novo Nordisk, Sanofi, Vifor. C. Fawcett is an employee of PRA Health Sciences. Drs Birmingham, Whang and Burton are employees of Janssen Scientific Affairs, LLC. Dr Januzzi is supported by the Hutter Family Professorship; is a Trustee of the American College of Cardiology; has received grant support from Applied Therapeutics and Novartis; has received consulting income from Abbott, Janssen, Novartis, Pfizer, Merck, and Roche Diagnostics; participates in clinical end point committees/data safety monitoring boards for Abbott, AbbVie, Amgen, Bayer, CVRx, Janssen, and Takeda. Dr Damaraju is an employee of Janssen Research & Development, LLC."

"Funding Sources Funding for this study has been provided by Janssen Scientific Affairs and PRA Health Sciences. Sources of Funding Funding for this study has been provided by Janssen Scientific Affairs and PRA Health Sciences."

"Registration:: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04252287."