EFFICACY AND SAFETY OF INTRAVITREAL AFLIBERCEPT USING A TREAT-AND-EXTEND REGIMEN FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: The ARIES Study: A Randomized Clinical Trial.

"P. Mitchell has received consulting fees from Bayer, Novartis, and Allergan and is an ARIES Steering Committee member. F. Holz has served as a consultant for Acucela, Apellis Pharmaceuticals, Bayer, Boehringer-Ingelheim, Bioeq/Formycon AG, Roche/Genentech, Geuder AG, Graybug Vision, Heidelberg Engineering, Chengdu Kanghong Pharmaceuticals, Lin Bioscience, Novartis, Pixium Vision, Oxurion, and Stealth BioTherapeutics; has received research support from Acucela, Apellis Pharmaceuticals, Bayer, Bioeq/Formycon AG, CenterVue, Roche/Genentech, Heidelberg Engineering, Chengdu Kanghong Pharmaceuticals, NightstaRx, Novartis, Optos, Pixium Vision, and Zeiss Pharma; has received honoraria or travel reimbursement from Acucela, Apellis Pharmaceuticals, Bayer, Ellex, Roche/Genentech, Graybug Vision, Heidelberg Engineering, Lin Bioscience, Novartis, Pixium Vision, Oxurion, Stealth BioTherapeutics, and Zeiss Pharma; and is an ARIES Steering Committee member. P. Hykin has received consultant fees from Bayer HealthCare, Novartis, and Allergan; has received travel support to participate in review activities for meetings from Bayer; has received support for provision of writing assistance, medicines, equipment, or administrative support from Bayer; has received payment for lectures and support for conference attendance from Allergan and Novartis; and is an ARIES Steering Committee member. S. Wolf has served as a consultant for Allergan, Bayer, Boehringer-Ingelheim, Chengdu Kanghong Biotech, Heidelberg Engineering, Novartis, Oxurion, Zeiss, and Roche; has received grant support from Heidelberg Engineering; and is an ARIES Steering Committee member. H. Allmeier, G. Lambrou, and T. Schmelter are employees of Bayer. T. Schmelter owns stocks of Bayer AG. E. Souied is an ARIES Steering Committee member. E. Midena is an ARIES Steering Committee member."

"Medical writing and editorial support for the preparation of this article was funded by Bayer Consumer Care AG, Switzerland. This study was sponsored by Bayer HealthCare AG, Germany."

"Trial Registration: ClinicalTrials.gov Identifier: NCT02581891 https://clinicaltrials.gov/ct2/show/NCT02581891. Supplemental Digital Contents (files 1 http://links.lww.com/IAE/B419)."