A novel mouse model of heatstroke accounting for ambient temperature and relative humidity.

"Declarations Ethics approval and consent to participateAll experimental procedures involving animals were approved and overseen by the Institutional Animal Care and Use Committee of Showa University, which adhered to the National Institutes of Health guidelines for ethical animal treatment (#05015). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding The project was supported by a Grant-in-Aid for Scientific Research C (15K10993, 19K09442, 19K22779) from the Japanese Ministry of Education, Culture, Sports, Science and Technology. The funds were used to purchase animals, PCR-related supplies, and blood chemistry testing."