Nationwide evaluation of mutation-tailored treatment of gastrointestinal stromal tumors in daily clinical practice.

"Declarations Conflict of interestThe authors declare that they have no conflict of interest. Outside the submitted work HG’s institution has relationships with Novartis, Bayer, Pfizer en Deciphera. SMW has relationships with BMS, Pfizer, Roche, AstraZeneca, Bayer, MSD, Amgen and Nextcure. KG is a scientific advisor to Bayer, Roche, Bristol-Myers Squibb, AstraZeneca and Amgen and is responsible for collaborations with Bristol-Myers Squibb, Milestone, Sakura, Illumina. Outside the submitted work MJLL has relationships with AstraZeneca, Bayer, Bristol-Myers Squibb, Illumina, Janssen Pharmaceuticals, Lilly, Merck Sharp & Dohme, Nimagen, and Roche. Ethics statementThe study was conducted in accordance with the Declaration of Helsinki and approved by the Local Ethical Committee of the Radboudumc (CMO 2016–2967). All data were handled according to the General Data Protection Regulation. Conflict of interest The authors declare that they have no conflict of interest. Outside the submitted work HG’s institution has relationships with Novartis, Bayer, Pfizer en Deciphera. SMW has relationships with BMS, Pfizer, Roche, AstraZeneca, Bayer, MSD, Amgen and Nextcure. KG is a scientific advisor to Bayer, Roche, Bristol-Myers Squibb, AstraZeneca and Amgen and is responsible for collaborations with Bristol-Myers Squibb, Milestone, Sakura, Illumina. Outside the submitted work MJLL has relationships with AstraZeneca, Bayer, Bristol-Myers Squibb, Illumina, Janssen Pharmaceuticals, Lilly, Merck Sharp & Dohme, Nimagen, and Roche."

"The authors thank the pathology departments that participate in the PATH project, the registration team of the Netherlands Comprehensive Cancer Organization (IKNL) for the collection of data for the Netherlands Cancer Registry, Eiko de Jong and Riki Willems for their critical discussions and support in the data collection, and Leonie Kroeze for her help in classification of mutations. This work was supported by the research program Personalized Medicine of the Netherlands Organization for Health research and Development (ZonMw, project number 846001001). The PATH consortium members: P. Drillenburg, E.W.P. Nijhuis: Onze Lieve Vrouwe Gasthuis, Amsterdam; M.J. van de Vijver, C.J. van Noesel: Amsterdam UMC, locatie AMC, Amsterdam; E. Bloemena, D.A.M. Heideman, T. Radonic, E. Thunissen: Amsterdam UMC, locatie VUmc, Amsterdam; P.M. Nederlof, G.A. Meijer, K. Monkhorst: Antoni van Leeuwenhoek, Amsterdam; H. Doornewaard: Gelre ziekenhuis, Apeldoorn; M.C.R.F. van Dijk, E. Ruijter: Rijnstate, Arnhem; K. Duthoi: Pathologisch en Cytologisch Laboratorium Amphia, Breda; C. Meijers: Reinier de Graaf Arash, Delft; A.J.C. van de Brule, P.T.G.A. Nooijen: Jeroen Bosch Ziekenhuis, Den Bosch; F.J. Bot: Hagaziekenhuis, Den Haag; H.M. Hazalbag, P. Clahsen: Medisch Centrum Haaglanden/ Bronovo, Den Haag; F.H. van Nederveen, P.J. Westenend: Laboratorium voor Pathologie, Dordrecht; J.W.M. Jeuken: Stichting PAMM, Eindhoven; E.J.M. Ahsmann, P. Meulbroek: Groene Hart Ziekenhuis, Gouda; W. Timens, E. Schuuring, L.C. van Kempen: Universitair Medisch Centrum Groningen, Groningen; W. Geuken: Martini Ziekenhuis, Groningen; N.W.J. Bulkmans, F.E. Bellot: Spaarne Gasthuis, Haarlem; R. Clarijs: Zuyderland Medisch centrum, Sittard-Geleen; E.H. Hofhuis, J. Meijer, H.J. van Slooten: PALGA, Houten; R.E. Kibbelaar, E.M.J. van der Logt: Pathologie Friesland, Leeuwarden; T. van Wezel: Leids Universitair Medisch Centrum, Leiden; A. Zur Hausen, E.J.M. Speel: Maastricht Universitair Medisch Centrum, Maastricht; P.C. de Bruin, C.J. Huijsmans: St. Antonius Ziekenhuis, Nieuwegein; S. Dusseljee, E. K. de Jong, R.W. Willems: Radboud universitair medisch centrum, Nijmegen; C.F. Prinsen, S. Zomer: Canisius-Wilhelmina Ziekenhuis, Nijmegen; F.J. van Kemenade, W.N.M. Dinjens, W.R.R. Geurts-Giele: Erasmus MC, Rotterdam; H. van der Valk, A.J.J. Smits, K.J. Hoogduin: Pathan BV, Rotterdam; M. Kliffen, M.A. den Bakker: Maasstad ziekenhuis, Rotterdam; J. Stavast: Elisabeth ziekenhuis, Tilburg; P.J. van Diest, W.W.J. de Leng: Universitair Medisch Centrum Utrecht, Utrecht; A.P. de Bruïne: VieCuri Medisch Centrum, Venlo; J.W.J. Hinrichs, C. Meischl: Symbiant BV, Alkmaar/Hoorn/Den Helder/Zaandam."