PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses.

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This work was supported by a grant from the 10.13039/501100003725National Research Foundation of Korea (NRF) funded by the Korean Government (10.13039/501100014188MSIT) (grant no. 2018R1A2A3075013, 2021R1C1C1009320, 2018M3A7B4071204, 2017R1A5A2015385, 2020R1A4A3078645, 2020R1A2C1004131, 2021R1C1C2006896, 2020R1A4A4079817). This research was supported by a grant of the Korea Health Technology R&D Project through the 10.13039/501100003710Korea Health Industry Development Institute (10.13039/501100003710KHIDI), funded by the 10.13039/501100003625Ministry of Health & Welfare, Republic of Korea (grant no. HI15C0001). Hee Ho Park, contributed equally to this study. Hyelim Kim, contributed equally to this study. Han Sol Lee, contributed equally to this study. Eun U Seo, contributed equally to this study. Ji-Eun Kim contributed equally to this study. Hee Ho Park: Conceptualization, Investigation, Writing – review & editing. Hyelim Kim: Methodology, Investigation. Han Sol Lee: Methodology, Investigation. Eun U Seo: Methodology, Investigation. Ji-Eun Kim: Methodology, Investigation. Jee-Hyun Lee: Resources. Yong-Hyeon Mun: Methodology, Investigation. So-Yeol Yoo: Methodology, Investigation. Jiseon An: Methodology, Investigation. Mi-Young Yun: Methodology. Nae-Won Kang: Investigation. Dea-Duk Kim: Supervision. Dong Hee Na: Supervision. Kyung Soo Hong: Resources. Jong Geol Jang: Resources. June Hong Ahn: Resources. Jong-Sup Bae: Supervision, Funding acquisition. Gyu Yong Song: Supervision, Methodology, Funding acquisition. Jae-Young Lee: Conceptualization, Supervision, Methodology, Funding acquisition, Writing – original draft. Hong Nam Kim: Conceptualization, Methodology, Supervision, Funding acquisition, Writing – original draft, Writing – review & editing. Wonhwa Lee: Conceptualization, Methodology, Validation, Supervision, Funding acquisition, Writing – original draft, review & editing."