The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis.

"sequencing data have been made available in the geo under accession number: gse134947."

"Declarations Conflict of interestThe authors declare that they have no conflict of interest. Conflict of interest The authors declare that they have no conflict of interest."

"We thank Arnoud Sonnenberg (Department of Cell Biology, Netherlands Cancer Institute, Amsterdam), Ben Morris and Roderick Beijersbergen (Robotics and Screening Center, Netherlands Cancer Institute, Amsterdam) and Nathan Lawson (UMass Medical School, Worcester, MA) for their kind gifts of materials. We gratefully acknowledge technical support from Paul Verkuijlen (Sanquin Research, Amsterdam), Simon Tol, Mark Hoogenboezen, and Erik Mul (Central Facility, Sanquin Research, Amsterdam), Lenny Brocks and Marjolijn Mertz (Digital microscopy facility, Netherlands Cancer Institute, Amsterdam), and Linda Koster (Sequencing core facility, Amsterdam University Medical Centers, Amsterdam). We thank Arnoud Sonnenberg for critical reading. This work was supported by research grants from the Netherlands Organisation for Scientific Research (ZonMW Veni 016.146.160) and the Dutch Thrombosis Foundation (2017-01) awarded to CM, Sanquin (PPOC 14-43) awarded to DdK, the Japan Society for the Promotion of Science Overseas Researcher Fellowships awarded to YW, and the Deutsche Forschungsgemeinschaft (HE4585/3-1), awarded to WH. We further acknowledge support from the Dutch Society for Cell Biology."