Does genetic anticipation occur in familial Alexander disease?

"Declarations Ethics approval/consent to participateNot applicable. Consent for publicationConsent was obtained from the proband of the family described. Competing interestsAmmar Al-Chalabi is a consultant for Mitsubishi-Tanabe Pharma, GSK, and Chronos Therapeutics and chief investigator for clinical trials for Cytokinetics and OrionPharma. All other authors declare no competing interests. Competing interests Ammar Al-Chalabi is a consultant for Mitsubishi-Tanabe Pharma, GSK, and Chronos Therapeutics and chief investigator for clinical trials for Cytokinetics and OrionPharma. All other authors declare no competing interests."

"Funding This is an EU Joint Programme—Neurodegenerative Disease Research (JPND) project. The project is supported through the following funding organisations under the aegis of JPND—www.jpnd.eu (United Kingdom, Medical Research Council (MR/L501529/1; MR/R024804/1) and Economic and Social Research Council (ES/L008238/1)). JS acknowledges funding support from the Rosetrees Trust (M799) and the van Geest Foundation."