The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide.

"Declarations Conflict of interestThe authors declare the following competing interests: C.C., J.P.R., M.Z., G.M.E., J.T., and T.B. are inventors of submitted Mexican (MX/E/2019/079075) and multinational (PCT/EP2020/069154) patent applications. The Universidad Nacional Autónoma de México (UNAM) and the authors J.T. and T.B. are owners of the pending patents. Ethical approvalAll experiments were approved by the Bioethics Committee of the Institute of Neurobiology of the National University of Mexico (UNAM). Conflict of interest The authors declare the following competing interests: C.C., J.P.R., M.Z., G.M.E., J.T., and T.B. are inventors of submitted Mexican (MX/E/2019/079075) and multinational (PCT/EP2020/069154) patent applications. The Universidad Nacional Autónoma de México (UNAM) and the authors J.T. and T.B. are owners of the pending patents."

"Funding This work was supported by grants A1-S-9620B and 289568 from “Consejo Nacional de Ciencia y Tecnología” (CONACYT) and UNAM grant 405PC to C.C. Magdalena Zamora is a doctoral student from ‘Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM)’ and received fellowship 768182 from CONACYT."